sequencing and imaging atlas of zebrafish development
Zebrahub is a comprehensive atlas of zebrafish embryonic development that combines single-cell RNA sequencing and live light-sheet imaging. Its aim is to provide a complete cartography of cellular lineages in space, time, and molecular domains, an essential step toward understanding how organisms develop.
Our ultimate goal is to create a high-quality multimodal foundational resource of vertebrate development and make it broadly available to the scientific community.
The atlas includes a high-resolution, single-embryo scRNAseq timecourse dataset covering 10 developmental stages from 10 hours post-fertilization to 10-day-old larvae, as well as image-based lineage reconstructions obtained from high-resolution light-sheet microscopy.
Zebrahub also provides open source instrument designs, software tools, and experimental protocols to help accelerate the adoption of these technologies and facilitate comprehension of vertebrate development.
Zebrahub - Multimodal Zebrafish Developmental Atlas Reveals the State Transition Dynamics of Late Vertebrate Pluripotent Axial Progenitors. Lange et al. BioRxiv 2023.
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